The mini-BioProducer membrane hollow fiber cartridges are small scale production cartridges for batch volumes between 5L – 250L and is also the perfect choice for scale up studies to Maximizer multi cartridge systems with membrane surface area > 20 m2. The membrane surface area is between 0.65 cm2 for the mini-BioProducer12 and up to 2.5 m2 for mini-BioProducer41.
The mini-BioProducer cartridges are available with WaterSep’s low binding antifouling modified polyethersulfon membrane with molecular weight cut-off (MWCO) from 3K to 750 K and 0.1 um, 0.2 um and 0.45 um. The fluid path length is similar to all other WaterSep HF cartridges which makes scale up/scale down easy and predictable. The mini-BioProducer re-use cartridges can be sanitized and cleaned in 0.5-1.0 N NaOH, and stored in 0.1 N NaOH between uses.
Typical applications are:
• Clarification of cell culture and fermentation suspensions in primary recovery applications.
• Cell harvest, excellent results have been achieved with both whole cell E.Coli and E. Coli lysates, as well as other microbial process streams.
• Concentration and purification of vaccines.
• Concentration/diafiltration of monoclonal antibodies, recombinant proteins, biological macromolecules and peptides.