The Researcher membrane hollow fiber cartridges are
positioned between the laboratory scale Explorer and the full pilot scale
Investigator cartridges. The membrane surface area is between 444 cm2 for the
Researcher12 and up to 1,715 cm2 for Researcher41 and are the perfect choice for
scale up/scale down studies and preparative biopharmaceutical work with sample
volumes between 400 ml up to 6000 ml
The Researcher cartridges are available with molecular weight cut-off (MWCO)
from 3K to 750 K and 0.1 um, 0.2 um and 0.45 um and with the same path length as
all other WaterSep HF cartridges which makes scale up/scale down easy and
predictable. The Researcher re-use cartridges can be sanitized and cleaned in
0.5-1.0 N NaOH, and stored in 0.1 N NaOH between usage.
Typical applications are:
clarification of cell culture and fermentation suspensions in primary
cell harvest, excellent results have been achieved with both whole cell
E.Coli and E. Coli lysates, as well as other microbial process streams.
concentration and purification of vaccines.
concentration/diafiltration of monoclonal antibodies, recombinant
proteins, biological macromolecules and peptides